› 7dv5

Electron Microscopy
3.7Å resolution

Human bile salt exporter ABCB11 in complex with taurocholate

Released:
DOI: 10.2210/pdb7dv5/pdb
PDB entry 7dv5 coloured by chain, front view.
PDB entry 7dv5 coloured by chain, side view.
PDB entry 7dv5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets.
Wang L, Hou WT, Wang J, Xu D, Guo C, Sun L, Ruan K, Zhou CZ, Chen Y
Cell Res 32 501-504 (2022)
PMID: 35043010
Related structures: EMD-30870

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131895 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bile salt export pump Chain: U
Molecule details ›
Chain: U
Length: 1270 amino acids
Theoretical weight: 140.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95342 (Residues: 46-1315; Coverage: 96%)
Gene names: ABCB11, BSEP
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand TCH 2 x TCH
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-30870
Expression system: Homo sapiens

Quick links

Citations

2 review citations

In silico modeling-based new alternative methods to predict drug and herb-induced liver injury: A review.
Shin et al. (2023)
1 more

2 mentions without citation

Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants.
Baatallah et al. (2022)
1 more