Function and Biology Details
Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase M2, peptidyl-dipeptidase A
- Immunoglobulin V-set domain
- Immunoglobulin domain subtype
- Immunoglobulin-like domain superfamily
- Immunoglobulin-like fold
- Immunoglobulin-like domain
- Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
- Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-209664 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Processed angiotensin-converting enzyme 2
Molecule details ›
Chain: A
Length: 597 amino acids
Theoretical weight: 69.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Angiotensin-converting enzyme
Length: 597 amino acids
Theoretical weight: 69.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q9BYF1 (Residues: 19-615; Coverage: 76%)
Sequence domains: Angiotensin-converting enzyme
Spike protein S1
Molecule details ›
Chain: E
Length: 194 amino acids
Theoretical weight: 21.78 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
Length: 194 amino acids
Theoretical weight: 21.78 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
- Canonical: P0DTC2 (Residues: 333-526; Coverage: 15%)
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
