› 7dxb

Electron Microscopy
2.7Å resolution

Structure of TRPC3 at 2.7 angstrom in high calcium state

Released:
DOI: 10.2210/pdb7dxb/pdb
PDB entry 7dxb coloured by chain, front view.
PDB entry 7dxb coloured by chain, side view.
PDB entry 7dxb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron 110 1023-1035.e5 (2022)
PMID: 35051376
Related structures: EMD-30903

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171729 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short transient receptor potential channel 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 836 amino acids
Theoretical weight: 96.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13507 (Residues: 86-921; Coverage: 91%)
Gene names: TRP3, TRPC3
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand POV 4 x POV
Ligand Y01 8 x Y01
Ligand ZN 4 x ZN
Ligand CA 12 x CA
Ligand 98R 4 x 98R
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-30903
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)
3 more

2 mentions without citation

Modulation and Regulation of Canonical Transient Receptor Potential 3 (TRPC3) Channels.
Cole et al. (2023)
1 more