› 7e2m

X-ray diffraction
2.35Å resolution

Crystal structure of the RWD domain of human GCN2 - 2

Released:
DOI: 10.2210/pdb7e2m/pdb
PDB entry 7e2m coloured by chain, front view.
PDB entry 7e2m coloured by chain, side view.
PDB entry 7e2m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2.
Hei Z, Wu S, Zheng L, Zhou J, Liu Z, Wang J, Fang P
Biochem Biophys Res Commun 549 164-170 (2021)
PMID: 33676185

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
eIF-2-alpha kinase GCN2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 135 amino acids
Theoretical weight: 15.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P2K8 (Residues: 17-139; Coverage: 8%)
Gene names: EIF2AK4, GCN2, KIAA1338
Sequence domains: RWD domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P63
Unit cell:
a: 158.44Å b: 158.44Å c: 54.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.234 0.261
Expression system: Escherichia coli

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