› 7e5m

X-ray diffraction
3.2Å resolution

crystal structure of trans assembled human TROP-2

Released:
DOI: 10.2210/pdb7e5m/pdb
PDB entry 7e5m coloured by chain, front view.
PDB entry 7e5m coloured by chain, side view.
PDB entry 7e5m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2.
Sun M, Zhang H, Jiang M, Chai Y, Qi J, Gao GF, Tan S
iScience 24 103190 (2021)
PMID: 34693228

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140741 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor-associated calcium signal transducer 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 236 amino acids
Theoretical weight: 26.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P09758 (Residues: 33-268; Coverage: 80%)
Gene names: GA733-1, M1S1, TACSTD2, TROP2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P21
Unit cell:
a: 51.543Å b: 126.882Å c: 54.072Å
α: 90° β: 118.39° γ: 90°
R-values:
R R work R free
0.248 0.239 0.284
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Mechanisms of Action and Limitations of Monoclonal Antibodies and Single Chain Fragment Variable (scFv) in the Treatment of Cancer.
Rodríguez-Nava et al. (2023)
2 other articles

3 mentions without citation

Targeting Trop2 in solid tumors: a look into structures and novel epitopes.
Liu et al. (2023)
2 more