› 7e75

X-ray diffraction
2.48Å resolution

Crystal structure of human ERK2 mutant (G37C)

Released:
DOI: 10.2210/pdb7e75/pdb
PDB entry 7e75 coloured by chain, front view.
PDB entry 7e75 coloured by chain, side view.
PDB entry 7e75 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism of inhibitor-resistance by ERK2 mutations
Park Y, Kim M, Ryu SE
Biodesign 9 14-18 (2021)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 41.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P21
Unit cell:
a: 48.82Å b: 70.536Å c: 60.243Å
α: 90° β: 109.4° γ: 90°
R-values:
R R work R free
0.184 0.184 0.266
Expression system: Escherichia coli

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