› 7e8e

Electron Microscopy
3.9Å resolution

CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex, transmembrane and intracellular region

Released:
DOI: 10.2210/pdb7e8e/pdb
PDB entry 7e8e coloured by chain, front view.
PDB entry 7e8e coloured by chain, side view.
PDB entry 7e8e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of gating modulation of Kv4 channel complexes.
Kise Y, Kasuya G, Okamoto HH, Yamanouchi D, Kobayashi K, Kusakizako T, Nishizawa T, Nakajo K, Nureki O
OpenAccess logo Nature 599 158-164 (2021)
PMID: 34552243
Related structures: EMD-31016

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-545196 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
A-type potassium channel modulatory protein KCNIP1 Chains: E, G
Molecule details ›
Chains: E, G
Length: 181 amino acids
Theoretical weight: 21.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZI2 (Residues: 47-227; Coverage: 80%)
Gene names: KCHIP1, KCNIP1, VABP
Sequence domains:
A-type voltage-gated potassium channel KCND2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 494 amino acids
Theoretical weight: 55.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZV8 (Residues: 2-495; Coverage: 78%)
Gene names: KCND2, KIAA1044
Sequence domains:
A-type potassium channel modulatory protein DPP6 Chains: I, K
Molecule details ›
Chains: I, K
Length: 31 amino acids
Theoretical weight: 3.03 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42658 (Residues: 94-120; Coverage: 3%)
Gene name: DPP6
A-type potassium channel modulatory protein KCNIP1 Chains: F, H
Molecule details ›
Chains: F, H
Length: 180 amino acids
Theoretical weight: 21.15 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZI2 (Residues: 48-227; Coverage: 79%)
Gene names: KCHIP1, KCNIP1, VABP
Sequence domains:
A-type potassium channel modulatory protein DPP6 Chains: J, L
Molecule details ›
Chains: J, L
Length: 28 amino acids
Theoretical weight: 2.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42658 (Residues: 94-120; Coverage: 3%)
Gene name: DPP6

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-31016
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Sensing sound: Cellular specializations and molecular force sensors.
Qiu et al. (2022)
6 more