7e8e

Electron Microscopy
3.9Å resolution

CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex, transmembrane and intracellular region

Released:
Source organism: Homo sapiens
Related structures: EMD-31016

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-154839 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
A-type potassium channel modulatory protein KCNIP1 Chains: E, G
Molecule details ›
Chains: E, G
Length: 181 amino acids
Theoretical weight: 21.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZI2 (Residues: 47-227; Coverage: 80%)
Gene names: KCHIP1, KCNIP1, VABP
Sequence domains:
A-type voltage-gated potassium channel KCND2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 494 amino acids
Theoretical weight: 55.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZV8 (Residues: 2-495; Coverage: 78%)
Gene names: KCND2, KIAA1044
Sequence domains:
A-type potassium channel modulatory protein DPP6 Chains: I, K
A-type potassium channel modulatory protein KCNIP1 Chains: F, H
A-type potassium channel modulatory protein DPP6 Chains: J, L

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.9Å
Relevant EMDB volumes: EMD-31016
Expression system: Homo sapiens