› 7e9b

X-ray diffraction
1.78Å resolution

Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy

Released:
DOI: 10.2210/pdb7e9b/pdb
PDB entry 7e9b coloured by chain, front view.
PDB entry 7e9b coloured by chain, side view.
PDB entry 7e9b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy.
Issafras H, Fan S, Tseng CL, Cheng Y, Lin P, Xiao L, Huang YJ, Tu CH, Hsiao YC, Li M, Chen YH, Ho CH, Li O, Wang Y, Chen S, Ji Z, Zhang E, Mao YT, Liu E, Yang S, Jiang W
OpenAccess logo PLoS One 16 e0257972 (2021)
PMID: 34972111

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-280170 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
heavy chain of Fab fragment of HLX10 Chain: H
Molecule details ›
Chain: H
Length: 215 amino acids
Theoretical weight: 22.83 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
light chain of Fab fragment of HLX10 Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Programmed cell death protein 1 Chain: C
Molecule details ›
Chain: C
Length: 115 amino acids
Theoretical weight: 12.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia phage EcSzw-2
UniProt:
  • Canonical: Q15116 (Residues: 32-146; Coverage: 44%)
Gene names: PD1, PDCD1
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P1
Unit cell:
a: 38.985Å b: 45.014Å c: 80.89Å
α: 93.6° β: 102.16° γ: 97.34°
R-values:
R R work R free
0.172 0.17 0.21
Expression systems:
  • Cricetulus griseus
  • Escherichia phage EcSzw-2

Quick links

Citations

4 review citations

Advances in immune checkpoint inhibitors therapy for small cell lung cancer.
Li et al. (2023)
3 more

1 mention without citation

ThermoPCD: a database of molecular dynamics trajectories of antibody-antigen complexes at physiologic and fever-range temperatures.
Singh et al. (2024)