› 7ecf

X-ray diffraction
1.6Å resolution

Crystal Structure of d(G4C2)2-Ba in C2221 space group

Released:
DOI: 10.2210/pdb7ecf/pdb
PDB entry 7ecf coloured by chain, front view.
PDB entry 7ecf coloured by chain, side view.
PDB entry 7ecf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence.
Geng Y, Liu C, Cai Q, Luo Z, Miao H, Shi X, Xu N, Fung CP, Choy TT, Yan B, Li N, Qian P, Zhou B, Zhu G
OpenAccess logo Nucleic Acids Res 49 5881-5890 (2021)
PMID: 34048588

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-121240 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*CP*C)-3') Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 12 nucleotides
Theoretical weight: 3.75 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand BA 7 x BA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: C2221
Unit cell:
a: 60.841Å b: 110.076Å c: 56.675Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.143 0.141 0.171
Expression system: Not provided

Quick links

Citations

4 review citations

Long-range DNA interactions: inter-molecular G-quadruplexes and their potential biological relevance.
Liano et al. (2022)
3 more

2 mentions without citation

Advances in the Structure of GGGGCC Repeat RNA Sequence and Its Interaction with Small Molecules and Protein Partners.
Liu et al. (2023)
1 more