7ega

Electron Microscopy
4.1Å resolution

TFIID-based intermediate PIC on PUMA promoter

Released:
Source organisms:
Related structures: EMD-31110

Function and Biology Details

Reactions catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
ATP + a protein = ADP + a phosphoprotein
ATP + H(2)O = ADP + phosphate
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)

Structure analysis Details

Assembly composition:
hetero 41-mer (preferred)
PDBe Complex ID:
PDB-CPX-236730 (preferred)
Entry contents:
33 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (35 distinct):
Transcription initiation factor TFIID subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 1872 amino acids
Theoretical weight: 212.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P21675 (Residues: 1-1893; Coverage: 99%)
  • Best match: P21675-1 (Residues: 1-1872)
Gene names: BA2R, CCG1, CCGS, TAF1, TAF2A
Sequence domains:
Transcription initiation factor TFIID subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 1199 amino acids
Theoretical weight: 137.16 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P1X5 (Residues: 1-1199; Coverage: 100%)
Gene names: CIF150, TAF2, TAF2B
Transcription initiation factor TFIID subunit 4 Chains: D, d
Transcription initiation factor TFIID subunit 5 Chains: E, e
Transcription initiation factor TFIID subunit 6 Chains: F, f
Transcription initiation factor TFIID subunit 7 Chain: G
Transcription initiation factor TFIID subunit 8 Chain: H
Transcription initiation factor TFIID subunit 9 Chains: I, i
Transcription initiation factor TFIID subunit 10 Chains: J, j
Transcription initiation factor TFIID subunit 12 Chains: L, l
Transcription initiation factor IIA subunit 2 Chain: O
TATA-box-binding protein Chain: P
Transcription initiation factor IIA subunit 1 Chain: Q
Transcription initiation factor IIB Chain: R
General transcription factor IIF subunit 1 Chain: S
General transcription factor IIF subunit 2 Chain: T
General transcription factor IIE subunit 1 Chain: U
Transcription initiation factor IIE subunit beta Chain: V
Transcription initiation factor TFIID subunit 3 Chain: c
Transcription initiation factor TFIID subunit 11 Chain: k
Transcription initiation factor TFIID subunit 13 Chain: m
DNA-directed RNA polymerase subunit Chain: o
DNA-directed RNA polymerase subunit beta Chain: p
DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein Chain: q
RNA polymerase Rpb4/RPC9 core domain-containing protein Chain: r
DNA-directed RNA polymerase II subunit E Chain: s
DNA-directed RNA polymerases I, II, and III subunit RPABC2 Chain: t
DNA-directed RNA polymerases I, II, and III subunit RPABC3 Chain: v
DNA-directed RNA polymerase II subunit RPB9 Chain: w
DNA-directed RNA polymerases I, II, and III subunit RPABC5 Chain: x
DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein Chain: y
RNA polymerase II, I and III subunit K Chain: z
DNA-directed RNA polymerase subunit Chain: u
DNA (85-MER) Chain: X
DNA (85-MER) Chain: Y

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-31110
Expression system: Homo sapiens