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EC 2.7.11.1: Non-specific serine/threonine protein kinase

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
  • A-kinase
  • AP50 kinase
  • ATP-protein transphosphorylase
  • Beta-IIPKC
  • Beta-adrenergic receptor kinase
  • CK-2
  • CKI
  • CKII
  • Calcium-dependent protein kinase C
  • Calcium/phospholipid-dependent protein kinase
  • Casein kinase
  • Casein kinase (phosphorylating)
  • Casein kinase 2
  • Casein kinase I
  • Casein kinase II
  • Cyclic AMP-dependent protein kinase
  • Cyclic AMP-dependent protein kinase A
  • Cyclic monophosphate-dependent protein kinase
  • Cyclic nucleotide-dependent protein kinase
  • Cyclin-dependent kinase
  • Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
  • Dsk1
  • Epsilon PKC
  • Glycogen synthase A kinase
  • Glycogen synthase a kinase
  • Glycogen synthase kinase
  • HIPK2
  • Hpr kinase
  • Hydroxyalkyl-protein kinase
  • M phase-specific cdc2 kinase
  • MAPK
  • Mitogen-activated S6 kinase
  • Mitogen-activated protein kinase
  • P82 kinase
  • PKA
  • PKC
  • Phosphorylase B kinase kinase
  • Phosphorylase b kinase kinase
  • Phosphorylase b kinase kinase
  • Protein glutamyl kinase
  • Protein kinase (phosphorylating)
  • Protein kinase A
  • Protein kinase CK2
  • Protein kinase p58
  • Protein phosphokinase
  • Protein serine kinase
  • Protein serine-threonine kinase
  • Protein-aspartyl kinase
  • Protein-cysteine kinase
  • Protein-serine kinase
  • Prp4 protein kinase
  • Raf kinase
  • Raf-1
  • Ribosomal S6 protein kinase
  • Ribosomal protein S6 kinase II
  • STK32
  • Serine kinase
  • Serine protein kinase
  • Serine(threonine) protein kinase
  • Serine-specific protein kinase
  • Serine/threonine protein kinase
  • T-antigen kinase
  • Threonine-specific protein kinase
  • Twitchin kinase
  • Type-2 casein kinase
  • WEE1Hu
  • Wee 1-like kinase
  • Wee-kinase
  • cAMP-dependent protein kinase
  • cAMP-dependent protein kinase A
  • cGMP-dependent protein kinase

EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
The deposited structure of PDB entry 7egi contains 12 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Transcription initiation factor TFIID subunit 5. Showing 6 copies in chain D [auth E].

PF03153
Domain description: Transcription factor IIA, alpha/beta subunit
Occurring in:
  1. Transcription initiation factor IIA subunit 1
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF03153 (Transcription factor IIA, alpha/beta subunit) in Transcription initiation factor IIA subunit 1. Showing 2 copies in chain M [auth Q].

PF00352
Domain description: Transcription factor TFIID (or TATA-binding protein, TBP)
Occurring in:
  1. TATA-box-binding protein
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF00352 (Transcription factor TFIID (or TATA-binding protein, TBP)) in TATA-box-binding protein. Showing 2 copies in chain L [auth P].

PF03847
Domain description: Transcription initiation factor TFIID subunit A
Occurring in:
  1. Transcription initiation factor TFIID subunit 12
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF03847 (Transcription initiation factor TFIID subunit A) in Transcription initiation factor TFIID subunit 12. Showing 1 copy in chain U [auth l].

PF03540
Domain description: Transcription initiation factor TFIID 23-30kDa subunit
Occurring in:
  1. Transcription initiation factor TFIID subunit 10
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF03540 (Transcription initiation factor TFIID 23-30kDa subunit) in Transcription initiation factor TFIID subunit 10. Showing 1 copy in chain S [auth j].

PF02291
Domain description: Transcription initiation factor IID, 31kD subunit
Occurring in:
  1. Transcription initiation factor TFIID subunit 9
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF02291 (Transcription initiation factor IID, 31kD subunit) in Transcription initiation factor TFIID subunit 9. Showing 1 copy in chain R [auth i].

PF07524
Domain description: Bromodomain associated
Occurring in:
  1. Transcription initiation factor TFIID subunit 8
  2. Transcription initiation factor TFIID subunit 3
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF07524 (Bromodomain associated) in Transcription initiation factor TFIID subunit 8. Showing 1 copy in chain G [auth H].
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF07524 (Bromodomain associated) in Transcription initiation factor TFIID subunit 3. Showing 1 copy in chain N [auth c].

PF07571
Domain description: TAF6 C-terminal HEAT repeat domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 6
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF07571 (TAF6 C-terminal HEAT repeat domain) in Transcription initiation factor TFIID subunit 6. Showing 1 copy in chain E [auth F].

PF02969
Domain description: TATA box binding protein associated factor (TAF)
Occurring in:
  1. Transcription initiation factor TFIID subunit 6
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF02969 (TATA box binding protein associated factor (TAF)) in Transcription initiation factor TFIID subunit 6. Showing 1 copy in chain E [auth F].

PF04494
Domain description: WD40 associated region in TFIID subunit, NTD2 domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF04494 (WD40 associated region in TFIID subunit, NTD2 domain) in Transcription initiation factor TFIID subunit 5. Showing 1 copy in chain D [auth E].

PF05236
Domain description: Transcription initiation factor TFIID component TAF4 family
Occurring in:
  1. Transcription initiation factor TFIID subunit 4
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF05236 (Transcription initiation factor TFIID component TAF4 family) in Transcription initiation factor TFIID subunit 4. Showing 1 copy in chain C [auth D].

PF07531
Domain description: NHR1 homology to TAF
Occurring in:
  1. Transcription initiation factor TFIID subunit 4
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF07531 (NHR1 homology to TAF) in Transcription initiation factor TFIID subunit 4. Showing 1 copy in chain C [auth D] (this domain is out of the observed residue ranges!).

PF00439
Domain description: Bromodomain
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
The deposited structure of PDB entry 7egi contains 2 copies of Pfam domain PF00439 (Bromodomain) in Transcription initiation factor TFIID subunit 1. Showing 2 copies in chain A (this domain is out of the observed residue ranges!).

PF02269
Domain description: Transcription initiation factor IID, 18kD subunit
Occurring in:
  1. Transcription initiation factor TFIID subunit 13
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF02269 (Transcription initiation factor IID, 18kD subunit) in Transcription initiation factor TFIID subunit 13. Showing 1 copy in chain V [auth m].

PF04719
Domain description: hTAFII28-like protein conserved region
Occurring in:
  1. Transcription initiation factor TFIID subunit 11
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF04719 (hTAFII28-like protein conserved region) in Transcription initiation factor TFIID subunit 11. Showing 1 copy in chain T [auth k].

PF00628
Domain description: PHD-finger
Occurring in:
  1. Transcription initiation factor TFIID subunit 3
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF00628 (PHD-finger) in Transcription initiation factor TFIID subunit 3. Showing 1 copy in chain N [auth c] (this domain is out of the observed residue ranges!).

PF02751
Domain description: Transcription initiation factor IIA, gamma subunit
Occurring in:
  1. Transcription initiation factor IIA subunit 2
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF02751 (Transcription initiation factor IIA, gamma subunit) in Transcription initiation factor IIA subunit 2. Showing 1 copy in chain K [auth O].

PF02268
Domain description: Transcription initiation factor IIA, gamma subunit, helical domain
Occurring in:
  1. Transcription initiation factor IIA subunit 2
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF02268 (Transcription initiation factor IIA, gamma subunit, helical domain) in Transcription initiation factor IIA subunit 2. Showing 1 copy in chain K [auth O].

PF10406
Domain description: Transcription factor TFIID complex subunit 8 C-term
Occurring in:
  1. Transcription initiation factor TFIID subunit 8
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF10406 (Transcription factor TFIID complex subunit 8 C-term ) in Transcription initiation factor TFIID subunit 8. Showing 1 copy in chain G [auth H].

PF04658
Domain description: TAFII55 protein conserved region
Occurring in:
  1. Transcription initiation factor TFIID subunit 7
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF04658 (TAFII55 protein conserved region) in Transcription initiation factor TFIID subunit 7. Showing 1 copy in chain F [auth G].

PF15288
Domain description: Zinc knuckle
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF15288 (Zinc knuckle) in Transcription initiation factor TFIID subunit 1. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

PF12157
Domain description: Protein of unknown function (DUF3591)
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF12157 (Protein of unknown function (DUF3591)) in Transcription initiation factor TFIID subunit 1. Showing 1 copy in chain A.

PF09247
Domain description: TATA box-binding protein binding
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
The deposited structure of PDB entry 7egi contains 1 copy of Pfam domain PF09247 (TATA box-binding protein binding) in Transcription initiation factor TFIID subunit 1. Showing 1 copy in chain A (this domain is out of the observed residue ranges!).

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Transcription initiation factor TFIID subunit 4
  2. Transcription initiation factor TFIID subunit 6
  3. Transcription initiation factor TFIID subunit 8
  4. Transcription initiation factor TFIID subunit 9
  5. Transcription initiation factor TFIID subunit 12
  6. Transcription initiation factor TFIID subunit 3
  7. Transcription initiation factor TFIID subunit 11
  8. Transcription initiation factor TFIID subunit 13
IPR003923
Domain description: Transcription initiation factor TFIID, 23-30kDa subunit
Occurring in:
  1. Transcription initiation factor TFIID subunit 10
IPR000814
Domain description: TATA-box binding protein
Occurring in:
  1. TATA-box-binding protein
IPR001487
Domain description: Bromodomain
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR003228
Domain description: Transcription initiation factor TFIID subunit 12 domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 12
IPR011442
Domain description: TAF6, C-terminal HEAT repeat domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 6
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
IPR003894
Domain description: TAFH/NHR1
Occurring in:
  1. Transcription initiation factor TFIID subunit 4
IPR004855
Domain description: Transcription factor IIA, alpha/beta subunit
Occurring in:
  1. Transcription initiation factor IIA subunit 1
IPR009088
Domain description: Transcription factor IIA, beta-barrel
Occurring in:
  1. Transcription initiation factor IIA subunit 2
  2. Transcription initiation factor IIA subunit 1
IPR003162
Domain description: Transcription initiation factor TAFII31
Occurring in:
  1. Transcription initiation factor TFIID subunit 9
IPR006565
Domain description: Bromodomain associated domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 8
  2. Transcription initiation factor TFIID subunit 3
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 6
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
IPR007582
Domain description: TFIID subunit TAF5, NTD2 domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
IPR037264
Domain description: TFIID subunit TAF5, NTD2 domain superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
IPR007900
Domain description: Transcription initiation factor TFIID component TAF4, C-terminal
Occurring in:
  1. Transcription initiation factor TFIID subunit 4
IPR037249
Domain description: TAFH/NHR1 domain superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 4
IPR036427
Domain description: Bromodomain-like superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR003195
Domain description: Transcription initiation factor IID, subunit 13
Occurring in:
  1. Transcription initiation factor TFIID subunit 13
IPR006751
Domain description: TAFII55 protein, conserved region
Occurring in:
  1. Transcription initiation factor TFIID subunit 7
IPR016024
Domain description: Armadillo-type fold
Occurring in:
  1. Transcription initiation factor TFIID subunit 2
  2. Transcription initiation factor TFIID subunit 6
IPR006809
Domain description: TAFII28-like protein domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 11
IPR019787
Domain description: Zinc finger, PHD-finger
Occurring in:
  1. Transcription initiation factor TFIID subunit 3
IPR012295
Domain description: TBP domain superfamily
Occurring in:
  1. TATA-box-binding protein
IPR015871
Domain description: Transcription initiation factor IIA, gamma subunit, C-terminal
Occurring in:
  1. Transcription initiation factor IIA subunit 2
IPR015872
Domain description: Transcription initiation factor IIA, gamma subunit, N-terminal
Occurring in:
  1. Transcription initiation factor IIA subunit 2
IPR037794
Domain description: Transcription initiation factor TFIID subunit 12
Occurring in:
  1. Transcription initiation factor TFIID subunit 12
IPR019473
Domain description: Transcription factor TFIID, subunit 8, C-terminal
Occurring in:
  1. Transcription initiation factor TFIID subunit 8
IPR046344
Domain description: TAF6, C-terminal HEAT repeat domain superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 6
IPR037796
Domain description: Transcription initiation factor TFIID subunit 6
Occurring in:
  1. Transcription initiation factor TFIID subunit 6
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
IPR006594
Domain description: LIS1 homology motif
Occurring in:
  1. Transcription initiation factor TFIID subunit 5
IPR045144
Domain description: Transcription initiation factor TFIID component TAF4
Occurring in:
  1. Transcription initiation factor TFIID subunit 4
IPR042097
Domain description: Aminopeptidase N-like , N-terminal domain superfamliy
Occurring in:
  1. Transcription initiation factor TFIID subunit 2
IPR036741
Domain description: TAFII-230 TBP-binding domain superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR045127
Domain description: Transcription initiation factor TFIID subunit 11-like
Occurring in:
  1. Transcription initiation factor TFIID subunit 11
IPR019786
Domain description: Zinc finger, PHD-type, conserved site
Occurring in:
  1. Transcription initiation factor TFIID subunit 3
IPR001965
Domain description: Zinc finger, PHD-type
Occurring in:
  1. Transcription initiation factor TFIID subunit 3
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. Transcription initiation factor TFIID subunit 3
IPR011011
Domain description: Zinc finger, FYVE/PHD-type
Occurring in:
  1. Transcription initiation factor TFIID subunit 3
IPR030491
Domain description: TATA-box binding protein, conserved site
Occurring in:
  1. TATA-box-binding protein
IPR033710
Domain description: TATA-box binding protein, eukaryotic
Occurring in:
  1. TATA-box-binding protein
IPR009083
Domain description: Transcription factor IIA, alpha-helical domain
Occurring in:
  1. Transcription initiation factor IIA subunit 2
IPR003194
Domain description: Transcription initiation factor IIA, gamma subunit
Occurring in:
  1. Transcription initiation factor IIA subunit 2
IPR037818
Domain description: Transcription initiation factor TFIID subunit 8
Occurring in:
  1. Transcription initiation factor TFIID subunit 8
IPR037817
Domain description: Transcription initiation factor TFIID subunit 7
Occurring in:
  1. Transcription initiation factor TFIID subunit 7
IPR027268
Domain description: Peptidase M4/M1, CTD superfamily
Occurring in:
  1. Transcription initiation factor TFIID subunit 2
IPR037813
Domain description: Transcription initiation factor TFIID subunit 2
Occurring in:
  1. Transcription initiation factor TFIID subunit 2
IPR018359
Domain description: Bromodomain, conserved site
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR041670
Domain description: Zinc knuckle
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR022591
Domain description: Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR009067
Domain description: TAFII-230 TBP-binding
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR040240
Domain description: Transcription initiation factor TFIID subunit 1
Occurring in:
  1. Transcription initiation factor TFIID subunit 1
IPR011177
Domain description: Transcription initiation factor TFIID subunit 1, animal
Occurring in:
  1. Transcription initiation factor TFIID subunit 1

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