7eh5

Electron Microscopy
4Å resolution

Cryo-EM structure of SARS-CoV-2 S-D614G variant in complex with neutralizing antibodies, RBD-chAb15 and RBD-chAb45

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
PDBe Complex ID:
PDB-CPX-210171 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1283 amino acids
Theoretical weight: 142.18 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
RBD-chAb45, heavy chain Chains: H, I, J
Molecule details ›
Chains: H, I, J
Length: 449 amino acids
Theoretical weight: 49.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
RBD-chAb15, light chain Chains: O, P, Q
Molecule details ›
Chains: O, P, Q
Length: 215 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
RBD-chAb15, heavy chain Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 449 amino acids
Theoretical weight: 49.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
RBD-chAb45, light chain Chains: L, M, N
Molecule details ›
Chains: L, M, N
Length: 214 amino acids
Theoretical weight: 23.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-31074
Expression system: Homo sapiens