7ehm

X-ray diffraction
2.13Å resolution

Human MTHFD2 in complex with compound 21 and 15

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-146835 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 34.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13995 (Residues: 36-350; Coverage: 90%)
Gene names: MTHFD2, NMDMC
Sequence domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSRRC BEAMLINE TPS 05A
Spacegroup: P65
Unit cell:
a: 114.232Å b: 114.232Å c: 114.164Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.195 0.227
Expression system: Escherichia coli