› 7ei4

X-ray diffraction
1.66Å resolution

Crystal structure of MasL in complex with a novel covalent inhibitor, collimonin C

Released:
DOI: 10.2210/pdb7ei4/pdb
PDB entry 7ei4 coloured by chain, front view.
PDB entry 7ei4 coloured by chain, side view.
PDB entry 7ei4 coloured by chain, top view.
Source organism: [Empedobacter] haloabium
Primary publication:
Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Lin CC, Hoo SY, Ma LT, Lin C, Huang KF, Ho YN, Sun CH, Lee HJ, Chen PY, Shu LJ, Wang BW, Hsu WC, Ko TP, Yang YL
OpenAccess logo Commun Biol 5 454 (2022)
PMID: 35551233

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-CoA C-acyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 407 amino acids
Theoretical weight: 42.61 KDa
Source organism: [Empedobacter] haloabium
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand J3U 4 x J3U
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE TPS 05A
Spacegroup: P21
Unit cell:
a: 59.139Å b: 115.077Å c: 125.789Å
α: 90° β: 91.08° γ: 90°
R-values:
R R work R free
0.117 0.114 0.162
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Discovery, mode of action and secretion of Burkholderia sensu lato key antimicrobial specialised metabolites.
Petrova et al. (2022)
4 other articles

1 mention without citation

Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Lin et al. (2022)