› 7el7

Solution NMR

NMR solution structure of the 1:1 complex of a quadruplex-duplex hybrid MYT1L and a platinum(II) ligand L1Pt(dien)

Released:
DOI: 10.2210/pdb7el7/pdb
PDB entry 7el7 coloured by chain, ensemble of 15 models, front view.
PDB entry 7el7 coloured by chain, ensemble of 15 models, side view.
PDB entry 7el7 coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Spatial Matching Selectivity and Solution Structure of Organic-Metal Hybrid to Quadruplex-Duplex Hybrid.
Liu LY, Wang KN, Liu W, Zeng YL, Hou MX, Yang J, Mao ZW
Angew Chem Int Ed Engl 60 20833-20839 (2021)
PMID: 34288320

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-121263 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
G-quadruplex DNA MYT1L Chain: A
Molecule details ›
Chain: A
Length: 29 nucleotides
Theoretical weight: 9.22 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand J70 1 x J70
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 citation in other articles

High-affinity binding at quadruplex-duplex junctions: rather the rule than the exception.
Vianney et al. (2022)
1 more

1 mention without citation

A Bio-Indicator Pilot Study Screening Selected Heavy Metals in Female Hair, Nails, and Serum from Lifestyle Cosmetic, Canned Food, and Manufactured Drink Choices.
Hamouda et al. (2023)