7emf

Electron Microscopy
3.5Å resolution

Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation

Released:
Source organism: Homo sapiens
Related structures: EMD-31191

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 27-mer (preferred)
PDBe Complex ID:
PDB-CPX-106078 (preferred)
Entry contents:
27 distinct polypeptide molecules
Macromolecules (27 distinct):
Mediator of RNA polymerase II transcription subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 1581 amino acids
Theoretical weight: 168.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Unknown Chain (poly A) Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 1.44 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Mediator of RNA polymerase II transcription subunit 4 Chain: D
Mediator of RNA polymerase II transcription subunit 6 Chain: F
Mediator of RNA polymerase II transcription subunit 7 Chain: G
Mediator of RNA polymerase II transcription subunit 8 Chain: H
Mediator of RNA polymerase II transcription subunit 9 Chain: I
Mediator of RNA polymerase II transcription subunit 10 Chain: J
Mediator of RNA polymerase II transcription subunit 11 Chain: K
Mediator of RNA polymerase II transcription subunit 14 Chain: N
Mediator of RNA polymerase II transcription subunit 15 Chain: O
Mediator of RNA polymerase II transcription subunit 16 Chain: P
Mediator of RNA polymerase II transcription subunit 17 Chain: Q
Mediator of RNA polymerase II transcription subunit 18 Chain: R
Mediator of RNA polymerase II transcription subunit 19 Chain: S
Mediator of RNA polymerase II transcription subunit 20 Chain: T
Mediator of RNA polymerase II transcription subunit 21 Chain: U
Mediator of RNA polymerase II transcription subunit 22 Chain: V
Mediator of RNA polymerase II transcription subunit 23 Chain: W
Mediator of RNA polymerase II transcription subunit 24 Chain: X
Mediator of RNA polymerase II transcription subunit 25 Chain: Y
Mediator of RNA polymerase II transcription subunit 26 Chain: Z
Mediator of RNA polymerase II transcription subunit 27 Chain: 0
Mediator of RNA polymerase II transcription subunit 28 Chain: 1
Mediator of RNA polymerase II transcription subunit 29 Chain: 2
Mediator of RNA polymerase II transcription subunit 30 Chain: 3
Mediator of RNA polymerase II transcription subunit 31 Chain: 4

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-31191
Expression system: Homo sapiens