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Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-after-condensation

Source organism: Pseudomonas aeruginosa PAO1
Biochemical function: phosphopantetheine binding
Biological process: antibiotic biosynthetic process
Cellular component: not assigned

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EC 6.2.1.69: L-cysteine--[L-cysteinyl-carrier protein] ligase

Reaction catalysed:
(1a) ATP + L-cysteine = diphosphate + (L-cysteinyl)adenylate
Systematic name:
L-cysteine:[L-cysteinyl-carrier protein] ligase (AMP-forming)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00550
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Pyochelin synthetase PchE
The deposited structure of PDB entry 7en1 contains 4 copies of Pfam domain PF00550 (Phosphopantetheine attachment site) in Pyochelin synthase PchE. Showing 2 copies in chain B (some of the copies are out of the observed residue ranges!).

PF00501
Domain description: AMP-binding enzyme
Occurring in:
  1. Pyochelin synthetase PchE
The deposited structure of PDB entry 7en1 contains 2 copies of Pfam domain PF00501 (AMP-binding enzyme) in Pyochelin synthase PchE. Showing 1 copy in chain B.

PF00668
Domain description: Condensation domain
Occurring in:
  1. Pyochelin synthetase PchE
The deposited structure of PDB entry 7en1 contains 2 copies of Pfam domain PF00668 (Condensation domain) in Pyochelin synthase PchE. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR036736
Domain description: ACP-like superfamily
Occurring in:
  1. Pyochelin synthetase PchE
IPR009081
Domain description: Phosphopantetheine binding ACP domain
Occurring in:
  1. Pyochelin synthetase PchE
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Pyochelin synthetase PchE
IPR045851
Domain description: AMP-binding enzyme, C-terminal domain superfamily
Occurring in:
  1. Pyochelin synthetase PchE
IPR006162
Domain description: Phosphopantetheine attachment site
Occurring in:
  1. Pyochelin synthetase PchE
IPR020806
Domain description: Polyketide synthase-like, phosphopantetheine-binding domain
Occurring in:
  1. Pyochelin synthetase PchE
IPR020845
Domain description: AMP-binding, conserved site
Occurring in:
  1. Pyochelin synthetase PchE
IPR010071
Domain description: Amino acid adenylation domain
Occurring in:
  1. Pyochelin synthetase PchE
IPR000873
Domain description: AMP-dependent synthetase/ligase domain
Occurring in:
  1. Pyochelin synthetase PchE
IPR042099
Domain description: ANL, N-terminal domain
Occurring in:
  1. Pyochelin synthetase PchE
IPR001242
Domain description: Condensation domain
Occurring in:
  1. Pyochelin synthetase PchE
IPR023213
Domain description: Chloramphenicol acetyltransferase-like domain superfamily
Occurring in:
  1. Pyochelin synthetase PchE

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