› 7erk

X-ray diffraction
1.7Å resolution

Crystal structure of V30M-TTR in complex with dasatinib

Released:
DOI: 10.2210/pdb7erk/pdb
PDB entry 7erk coloured by chain, front view.
PDB entry 7erk coloured by chain, side view.
PDB entry 7erk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors.
Yokoyama T, Kashihara M, Mizuguchi M
J Med Chem 64 14344-14357 (2021)
PMID: 34547896

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 159 amino acids
Theoretical weight: 17.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 1-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

1 bound ligand:
Ligand 1N1 2 x 1N1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 43.174Å b: 85.644Å c: 63.609Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.19 0.222
Expression system: Escherichia coli

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