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Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with tricyclic small molecule inhibitor JBSNF-000028

Source organism: Homo sapiens
Biochemical function: pyridine N-methyltransferase activity
Biological process: positive regulation of protein deacetylation
Cellular component: cytosol

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EC 2.1.1.1: Nicotinamide N-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide
Systematic name:
S-adenosyl-L-methionine:nicotinamide N-methyltransferase
Alternative Name(s):
  • Nicotinamide methyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01234
Domain description: NNMT/PNMT/TEMT family
Occurring in:
  1. Nicotinamide N-methyltransferase
The deposited structure of PDB entry 7et7 contains 4 copies of Pfam domain PF01234 (NNMT/PNMT/TEMT family) in Nicotinamide N-methyltransferase. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR000940
Domain description: Methyltransferase, NNMT/PNMT/TEMT
Occurring in:
  1. Nicotinamide N-methyltransferase
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Nicotinamide N-methyltransferase
IPR025820
Domain description: Methyltransferase NNMT/PNMT/TEMT, conserved site
Occurring in:
  1. Nicotinamide N-methyltransferase
IPR036393
Domain description: Acetylglutamate kinase-like superfamily
Occurring in:
  1. Nicotinamide N-methyltransferase

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