› 7eu8

Electron Microscopy
4.07Å resolution

Structure of the human GluN1-GluN2B NMDA receptor in complex with S-ketamine,glycine and glutamate

Released:
DOI: 10.2210/pdb7eu8/pdb
PDB entry 7eu8 coloured by chain, front view.
PDB entry 7eu8 coloured by chain, side view.
PDB entry 7eu8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of ketamine action on human NMDA receptors.
Zhang Y, Ye F, Zhang T, Lv S, Zhou L, Du D, Lin H, Guo F, Luo C, Zhu S
Nature 596 301-305 (2021)
PMID: 34321660
Related structures: EMD-31309

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170225 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor ionotropic, NMDA 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 847 amino acids
Theoretical weight: 95.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q05586 (Residues: 1-847; Coverage: 90%)
Gene names: GRIN1, NMDAR1
Sequence domains:
Glutamate receptor ionotropic, NMDA 2B Chains: B, D
Molecule details ›
Chains: B, D
Length: 862 amino acids
Theoretical weight: 96.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13224 (Residues: 1-842; Coverage: 56%)
Gene names: GRIN2B, NMDAR2B
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 7 x NAG
Ligand JC9 1 x JC9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.07Å
Relevant EMDB volumes: EMD-31309
Expression system: Homo sapiens

Quick links

Citations

16 review citations

Mechanisms of ketamine and its metabolites as antidepressants.
Hess et al. (2022)
15 more

11 mentions without citation

Structural insights into NMDA receptor pharmacology.
Zhou et al. (2023)
10 more