7ewr

Electron Microscopy
4.7Å resolution

Cryo-EM structure of human GPR158 in complex with RGS7-Gbeta5 in a 2:2:2 ratio

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5.
OpenAccess logo Nat Commun 12 6805 (2021)
PMID: 34815401
Related structures: EMD-31363

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-127123 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Regulator of G-protein signaling 7 Chains: C, E
Molecule details ›
Chains: C, E
Length: 530 amino acids
Theoretical weight: 61.57 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P49802 (Residues: 1-495; Coverage: 100%)
Gene name: RGS7
Sequence domains:
Guanine nucleotide-binding protein subunit beta-5 Chains: D, F
Molecule details ›
Chains: D, F
Length: 395 amino acids
Theoretical weight: 43.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O14775 (Residues: 1-395; Coverage: 100%)
Gene name: GNB5
Sequence domains: WD domain, G-beta repeat
Metabotropic glycine receptor Chains: A, B

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.7Å
Relevant EMDB volumes: EMD-31363
Expression system: Homo sapiens