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Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 16

Source organism: Ebinur lake virus
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF15518
Domain description: L protein N-terminus
Occurring in:
  1. RNA-directed RNA polymerase L
The deposited structure of PDB entry 7ex7 contains 4 copies of Pfam domain PF15518 (L protein N-terminus) in RNA-directed RNA polymerase L. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR048006
Domain description: RNA endonuclease, cap-snatching, bunyaviral
Occurring in:
  1. RNA-directed RNA polymerase L
IPR029124
Domain description: RNA-directed RNA polymerase L, N-terminal
Occurring in:
  1. RNA-directed RNA polymerase L
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. RNA-directed RNA polymerase L

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