Function and Biology

Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with ANP

Source organism: Escherichia coli BL21(DE3)
Biochemical function: protein binding
Biological process: heme import across plasma membrane
Cellular component: ATP-binding cassette (ABC) transporter complex

EC 7.6.2.5: ABC-type heme transporter

Reaction catalysed:
ATP + H(2)O + heme(Side 1) = ADP + phosphate + heme(Side 2)
Systematic name:
ATP phosphohydrolase (ABC-type, heme-exporting)
Alternative Name(s):
  • Heme-transporting ATPase

Sequence families

Pfam Protein families (Pfam)
PF03379
Domain description: CcmB protein
Occurring in:
  1. Heme exporter protein B
The deposited structure of PDB entry 7f03 contains 2 copies of Pfam domain PF03379 (CcmB protein) in Heme exporter protein B. Showing 1 copy in chain B.

PF00005
Domain description: ABC transporter
Occurring in:
  1. Cytochrome c biogenesis ATP-binding export protein CcmA
The deposited structure of PDB entry 7f03 contains 2 copies of Pfam domain PF00005 (ABC transporter) in Cytochrome c biogenesis ATP-binding export protein CcmA. Showing 1 copy in chain A.

PF04995
Domain description: Heme exporter protein D (CcmD)
Occurring in:
  1. Heme exporter protein D
The deposited structure of PDB entry 7f03 contains 1 copy of Pfam domain PF04995 (Heme exporter protein D (CcmD)) in Heme exporter protein D. Showing 1 copy in chain D.

PF01578
Domain description: Cytochrome C assembly protein
Occurring in:
  1. Heme exporter protein C
The deposited structure of PDB entry 7f03 contains 1 copy of Pfam domain PF01578 (Cytochrome C assembly protein) in Heme exporter protein C. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR003557
Domain description: Cytochrome c-type biogenesis protein CcmC
Occurring in:
  1. Heme exporter protein C
IPR026031
Domain description: Cytochrome c-type biogenesis protein CcmB, bacteria
Occurring in:
  1. Heme exporter protein B
IPR003544
Domain description: Cytochrome c-type biogenesis protein CcmB
Occurring in:
  1. Heme exporter protein B
IPR003439
Domain description: ABC transporter-like, ATP-binding domain
Occurring in:
  1. Cytochrome c biogenesis ATP-binding export protein CcmA
IPR005895
Domain description: ABC transporter, haem export, CcmA
Occurring in:
  1. Cytochrome c biogenesis ATP-binding export protein CcmA
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Cytochrome c biogenesis ATP-binding export protein CcmA
IPR007078
Domain description: Haem exporter protein D (CcmD)
Occurring in:
  1. Heme exporter protein D
IPR017871
Domain description: ABC transporter-like, conserved site
Occurring in:
  1. Cytochrome c biogenesis ATP-binding export protein CcmA
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Cytochrome c biogenesis ATP-binding export protein CcmA
IPR045062
Domain description: Cytochrome c-type biogenesis protein CcsA/CcmC
Occurring in:
  1. Heme exporter protein C
IPR002541
Domain description: Cytochrome c assembly protein
Occurring in:
  1. Heme exporter protein C