› 7f29

Electron Microscopy
3.1Å resolution

Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42)

Released:
DOI: 10.2210/pdb7f29/pdb
PDB entry 7f29 coloured by chain, front view.
PDB entry 7f29 coloured by chain, side view.
PDB entry 7f29 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation
Liu D, Wei Q, Xia W, He C, Zhang Q, Huang L, Wang X, Sun Y, Ma Y, Zhang X, Wang Y, Shi X, Liu C, Dong S
J. Am. Chem. Soc. 143 20216-20223 (2021)
Related structures: EMD-31428

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-529017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Amyloid-beta protein 40 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 37 amino acids
Theoretical weight: 3.9 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 677-713; Coverage: 5%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

Carbohydrate polymer : NEW Components: X6X, GAL
Carbohydrate polymer
1 bound ligand:
Ligand ACY 6 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-31428
Expression system: Not provided

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