› 7f3u

Electron Microscopy
4Å resolution

Cryo-EM structure of human TMEM120A in the CoASH-free state

Released:
DOI: 10.2210/pdb7f3u/pdb
PDB entry 7f3u coloured by chain, front view.
PDB entry 7f3u coloured by chain, side view.
PDB entry 7f3u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.
Rong Y, Jiang J, Gao Y, Guo J, Song D, Liu W, Zhang M, Zhao Y, Xiao B, Liu Z
OpenAccess logo Elife 10 (2021)
PMID: 34409941
Related structures: EMD-31441

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189791 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion channel TACAN Chains: A, B
Molecule details ›
Chains: A, B
Length: 375 amino acids
Theoretical weight: 44.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BXJ8 (Residues: 2-343; Coverage: 100%)
Gene names: TACAN, TMEM120A, TMPIT
Sequence domains: TMPIT-like protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-31441
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Force From Filaments: The Role of the Cytoskeleton and Extracellular Matrix in the Gating of Mechanosensitive Channels.
Chuang et al. (2022)
2 more

2 mentions without citation

Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles.
Kang et al. (2024)
1 more