› 7f5o

X-ray diffraction
1.7Å resolution

Crystal structure of PTPN2 catalytic domain

Released:
DOI: 10.2210/pdb7f5o/pdb
PDB entry 7f5o coloured by chain, front view.
PDB entry 7f5o coloured by chain, side view.
PDB entry 7f5o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity.
Singh JP, Lin MJ, Hsu SF, Peti W, Lee CC, Meng TC
Biochemistry 60 3856-3867 (2021)
PMID: 34910875

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148138 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 305 amino acids
Theoretical weight: 35.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17706 (Residues: 1-302; Coverage: 73%)
Gene names: PTPN2, PTPT
Sequence domains: Protein-tyrosine phosphatase

Ligands and Environments

1 bound ligand:
Ligand IOD 6 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL15A1
Spacegroup: P1
Unit cell:
a: 55.094Å b: 68.187Å c: 72.683Å
α: 111.54° β: 102.659° γ: 92.337°
R-values:
R R work R free
0.201 0.199 0.241
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Protein tyrosine phosphatase non-receptor type 2 as the therapeutic target of atherosclerotic diseases: past, present and future.
Tang et al. (2023)
1 more

1 mention without citation

Discovery of a selective TC-PTP degrader for cancer immunotherapy.
Miao et al. (2023)