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GK domain of Drosophila P5CS filament with glutamate

Source organism: Drosophila melanogaster
Biochemical function: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological process: L-proline biosynthetic process
Cellular component: mitochondrial matrix

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EC 2.7.2.11: Glutamate 5-kinase

Reaction catalysed:
ATP + L-glutamate = ADP + L-glutamate 5-phosphate
Systematic name:
ATP:L-glutamate 5-phosphotransferase
Alternative Name(s):
  • ATP-L-glutamate 5-phosphotransferase
  • ATP:gamma-L-glutamate phosphotransferase
  • Gamma-glutamate kinase
  • Gamma-glutamyl kinase
  • Glutamate kinase

EC 1.2.1.41: Glutamate-5-semialdehyde dehydrogenase

Reaction catalysed:
L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH
Systematic name:
L-glutamate-5-semialdehyde:NADP(+) 5-oxidoreductase (phosphorylating)
Alternative Name(s):
  • Beta-glutamylphosphate reductase
  • Gamma-glutamyl phosphate reductase
  • Gamma-glutamylphosphate reductase
  • Glutamate semialdehyde dehydrogenase
  • Glutamate-gamma-semialdehyde dehydrogenase
  • Glutamyl-gamma-semialdehyde dehydrogenase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00171
Domain description: Aldehyde dehydrogenase family
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
The deposited structure of PDB entry 7f5x contains 4 copies of Pfam domain PF00171 (Aldehyde dehydrogenase family) in Delta-1-pyrroline-5-carboxylate synthase. Showing 1 copy in chain A.

PF00696
Domain description: Amino acid kinase family
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
The deposited structure of PDB entry 7f5x contains 4 copies of Pfam domain PF00696 (Amino acid kinase family) in Delta-1-pyrroline-5-carboxylate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001057
Domain description: Glutamate/acetylglutamate kinase
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR000965
Domain description: GPR domain
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR036393
Domain description: Acetylglutamate kinase-like superfamily
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR005715
Domain description: Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR005766
Domain description: Delta l-pyrroline-5-carboxylate synthetase
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR020593
Domain description: Gamma-glutamyl phosphate reductase GPR, conserved site
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR016163
Domain description: Aldehyde dehydrogenase, C-terminal
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR016162
Domain description: Aldehyde dehydrogenase, N-terminal
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR016161
Domain description: Aldehyde/histidinol dehydrogenase
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR015590
Domain description: Aldehyde dehydrogenase domain
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR019797
Domain description: Glutamate 5-kinase, conserved site
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR001048
Domain description: Aspartate/glutamate/uridylate kinase
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase
IPR041744
Domain description: Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain
Occurring in:
  1. Delta-1-pyrroline-5-carboxylate synthase

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