› 7f61

X-ray diffraction
2.6Å resolution

Crystal structure of human histamine receptor H3R in complex with antagonist PF03654746

Released:
DOI: 10.2210/pdb7f61/pdb
PDB entry 7f61 coloured by chain, front view.
PDB entry 7f61 coloured by chain, side view.
PDB entry 7f61 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for recognition of antihistamine drug by human histamine receptor.
Peng X, Yang L, Liu Z, Lou S, Mei S, Li M, Chen Z, Zhang H
OpenAccess logo Nat Commun 13 6105 (2022)
PMID: 36243875

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142152 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histamine H3 receptor Chain: A
Molecule details ›
Chain: A
Length: 407 amino acids
Theoretical weight: 45.01 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y5N1 (Residues: 27-433; Coverage: 92%)
Gene names: GPCR97, HRH3
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Soluble cytochrome b562 Chain: B
Molecule details ›
Chain: B
Length: 147 amino acids
Theoretical weight: 16.83 KDa
Source organism: Escherichia coli
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
Gene name: cybC
Sequence domains: Cytochrome b562

Ligands and Environments

2 bound ligands:
Ligand 1IB 1 x 1IB
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P21212
Unit cell:
a: 71.124Å b: 165.624Å c: 42.651Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.229 0.285
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

G<sub>12/13</sub> signaling in asthma.
McDuffie et al. (2024)
6 other articles

10 mentions without citation

A Perspective on Protein Structure Prediction Using Quantum Computers.
Doga et al. (2024)
9 more