› 7f7l

X-ray diffraction
2.25Å resolution

Crystal structure of AKR4C17 bound with NADPH

Released:
DOI: 10.2210/pdb7f7l/pdb
PDB entry 7f7l coloured by chain, front view.
PDB entry 7f7l coloured by chain, side view.
PDB entry 7f7l coloured by chain, top view.
Source organism: Echinochloa colona
Primary publication:
Structural analysis and engineering of aldo-keto reductase from glyphosate-resistant Echinochloa colona
Li H, Yang Y, Hu Y, Chen CC, Huang JW, Min J, Dai L, Guo RT
J Hazard Mater 436 129191- (2022)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-498106 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NADP-dependent oxidoreductase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 321 amino acids
Theoretical weight: 35.34 KDa
Source organism: Echinochloa colona
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A5J6VLZ7 (Residues: 1-310; Coverage: 100%)
Sequence domains: Aldo/keto reductase family

Ligands and Environments

3 bound ligands:
Ligand CO 1 x CO
Ligand NDP 2 x NDP
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE TPS 05A
Spacegroup: P6122
Unit cell:
a: 77.426Å b: 77.426Å c: 452.752Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.183 0.181 0.226
Expression system: Escherichia coli BL21(DE3)

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