› 7f8u

X-ray diffraction
2.8Å resolution

Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript

Released:
DOI: 10.2210/pdb7f8u/pdb
PDB entry 7f8u coloured by chain, front view.
PDB entry 7f8u coloured by chain, side view.
PDB entry 7f8u coloured by chain, top view.
Source organisms:
Primary publication:
Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q
Nat Chem Biol 17 1230-1237 (2021)
PMID: 34556863

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132974 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cholecystokinin receptor type A; Endolysin Chain: A
Molecule details ›
Chain: A
Length: 534 amino acids
Theoretical weight: 60.45 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P32238 (Residues: 37-240, 302-375; Coverage: 65%)
  • Canonical: P00720 (Residues: 2-161; Coverage: 98%)
Gene names: CCKAR, CCKRA, E
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand 1OE 1 x 1OE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 54.41Å b: 71.92Å c: 86.05Å
α: 90° β: 106.13° γ: 90°
R-values:
R R work R free
0.236 0.236 0.253
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors.
He et al. (2023)
3 more

3 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
2 more