› 7fcr

X-ray diffraction
1.4Å resolution

Crystal structure of the N-terminal domain of mutants of Human Apolipoprotein-E (ApoE)

Released:
DOI: 10.2210/pdb7fcr/pdb
PDB entry 7fcr coloured by chain, front view.
PDB entry 7fcr coloured by chain, side view.
PDB entry 7fcr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Cherakara S, Kumar A, Garai K, Ghosh B

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein E Chain: A
Molecule details ›
Chain: A
Length: 193 amino acids
Theoretical weight: 22.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02649 (Residues: 19-209; Coverage: 64%)
Gene name: APOE
Sequence domains: Apolipoprotein A1/A4/E domain

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RRCAT INDUS-2 BEAMLINE PX-BL21
Spacegroup: P212121
Unit cell:
a: 40.642Å b: 53.207Å c: 85.982Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.171 0.194
Expression system: Escherichia coli BL21(DE3)

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