› 7fdv

Electron Microscopy
3.26Å resolution

Cryo-EM structure of the human cholesterol transporter ABCG1 in complex with cholesterol

Released:
DOI: 10.2210/pdb7fdv/pdb
PDB entry 7fdv coloured by chain, front view.
PDB entry 7fdv coloured by chain, side view.
PDB entry 7fdv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and transport mechanism of the human cholesterol transporter ABCG1.
Xu D, Li Y, Yang F, Sun CR, Pan J, Wang L, Chen ZP, Fang SC, Yao X, Hou WT, Zhou CZ, Chen Y
Cell Rep 38 110298 (2022)
PMID: 35081353
Related structures: EMD-31547

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-545720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family G member 1 Chains: A, D
Molecule details ›
Chains: A, D
Length: 678 amino acids
Theoretical weight: 75.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P45844 (Residues: 1-678; Coverage: 100%)
Gene names: ABC8, ABCG1, WHT1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ATP 2 x ATP
Ligand HWP 2 x HWP
Ligand CLR 2 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.26Å
Relevant EMDB volumes: EMD-31547
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Upstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias.
Cooper et al. (2024)
2 more

2 mentions without citation

Snapshots of ABCG1 and ABCG5/G8: A Sterol's Journey to Cross the Cellular Membranes.
Rezaei et al. (2022)
1 more