Function and Biology Details
Reactions catalysed:
Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
NTP + H(2)O = NDP + phosphate
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 360-mer (preferred)
PDBe Complex ID:
PDB-CPX-207746 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
VP1
Molecule details ›
Chain: 1
Length: 212 amino acids
Theoretical weight: 23.4 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
Sequence domains: Picornavirus coat protein
Length: 212 amino acids
Theoretical weight: 23.4 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
- Canonical:
E7D639 (Residues: 1-212; Coverage: 100%)
Sequence domains: Picornavirus coat protein
Capsid protein VP0
Molecule details ›
Chain: 2
Length: 218 amino acids
Theoretical weight: 24.54 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
Length: 218 amino acids
Theoretical weight: 24.54 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
- Canonical: D0E7R9 (Residues: 287-504; Coverage: 9%)
Capsid protein VP0
Molecule details ›
Chain: 3
Length: 221 amino acids
Theoretical weight: 24.16 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
Length: 221 amino acids
Theoretical weight: 24.16 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
- Canonical: D0E7S2 (Residues: 505-725; Coverage: 10%)
Capsid protein VP4
Molecule details ›
Chain: 4
Length: 85 amino acids
Theoretical weight: 8.78 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
Length: 85 amino acids
Theoretical weight: 8.78 KDa
Source organism: Foot-and-mouth disease virus A
UniProt:
- Canonical: P03309 (Residues: 202-286; Coverage: 4%)
