Function and Biology Details
Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase S3, togavirin
- Flaviviral glycoprotein E, dimerisation domain
- Peptidase S1, PA clan, chymotrypsin-like fold
- Immunoglobulin E-set
- Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily
- Flavivirus glycoprotein, central and dimerisation domain superfamily
- Alphavirus E1 glycoprotein
- Alphavirus E2 glycoprotein, domain C
5 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Capsid protein (preferred)
PDBe Complex ID:
PDB-CPX-138733 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Capsid protein
Molecule details ›
Chain: K
Length: 275 amino acids
Theoretical weight: 30.98 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Homo sapiens
UniProt:
Length: 275 amino acids
Theoretical weight: 30.98 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Homo sapiens
UniProt:
- Canonical:
P05674 (Residues: 1-275; Coverage: 22%)
Assembly protein E3
Molecule details ›
Chain: L
Length: 59 amino acids
Theoretical weight: 6.49 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Homo sapiens
UniProt:
Length: 59 amino acids
Theoretical weight: 6.49 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Homo sapiens
UniProt:
- Canonical: P05674 (Residues: 276-334; Coverage: 5%)
Spike glycoprotein E2
Molecule details ›
Chain: N
Length: 423 amino acids
Theoretical weight: 47.11 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Homo sapiens
UniProt:
Length: 423 amino acids
Theoretical weight: 47.11 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Homo sapiens
UniProt:
- Canonical: P05674 (Residues: 335-757; Coverage: 34%)
Spike glycoprotein E1
Molecule details ›
Chain: O
Length: 442 amino acids
Theoretical weight: 47.95 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Homo sapiens
UniProt:
Length: 442 amino acids
Theoretical weight: 47.95 KDa
Source organism: Venezuelan equine encephalitis virus (strain TC-83)
Expression system: Homo sapiens
UniProt:
- Canonical: P05674 (Residues: 813-1254; Coverage: 35%)
