› 7fhq

Solution NMR

Solution structure of the pathogenic mutant G131V of Human prion protein (91-231)

Released:
DOI: 10.2210/pdb7fhq/pdb
PDB entry 7fhq coloured by chain, ensemble of 20 models, front view.
PDB entry 7fhq coloured by chain, ensemble of 20 models, side view.
PDB entry 7fhq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Zhang H, Lin D

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 142 amino acids
Theoretical weight: 16.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04156 (Residues: 91-231; Coverage: 61%)
Gene names: ALTPRP, PRIP, PRNP, PRP
Sequence domains: Prion/Doppel alpha-helical domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 68%
Refinement method: simulated annealing
Expression system: Escherichia coli

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