› 7fif

Electron Microscopy
6.5Å resolution

Cryo-EM structure of the hedgehog release protein Disp from water bear (Hypsibius dujardini)

Released:
DOI: 10.2210/pdb7fif/pdb
PDB entry 7fif coloured by chain, front view.
PDB entry 7fif coloured by chain, side view.
PDB entry 7fif coloured by chain, top view.
Source organism: Hypsibius dujardini
Primary publication:
Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release.
Luo Y, Wan G, Zhou X, Wang Q, Zhang Y, Bao J, Cong Y, Zhao Y, Li D
OpenAccess logo Front Mol Biosci 8 701826 (2021)
PMID: 34557519
Related structures: EMD-31595

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103825 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SSD domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 1118 amino acids
Theoretical weight: 124.94 KDa
Source organism: Hypsibius dujardini
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1W0WWK2 (Residues: 2-1116; Coverage: 92%)
Gene name: BV898_06340
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.5Å
Relevant EMDB volumes: EMD-31595
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

From mesenchymal niches to engineered in vitro model systems: Exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling.
Ghuloum et al. (2022)