› 7ftj

X-ray diffraction
1.46Å resolution

Crystal Structure of apo human cyclic GMP-AMP synthase

Released:
DOI: 10.2210/pdb7ftj/pdb
PDB entry 7ftj coloured by chain, front view.
PDB entry 7ftj coloured by chain, side view.
PDB entry 7ftj coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Leibrock L, Benz J, Groebke-Zbinden K, Rudolph MG

Function and Biology Details

Reaction catalysed: 
(1a) ATP + GTP = pppG-P(2'-5')A + diphosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic GMP-AMP synthase Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 42.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N884 (Residues: 161-522; Coverage: 69%)
Gene names: C6orf150, CGAS, MB21D1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Unit cell:
a: 47.886Å b: 57.293Å c: 122.106Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.21
Expression system: Escherichia coli BL21(DE3)

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