› 7gub

X-ray diffraction
1.94Å resolution

PanDDA analysis group deposition of ground-state model of PTP1B, using pre-clustering, cluster19

Released:
DOI: 10.2210/pdb7gub/pdb
PDB entry 7gub coloured by chain, front view.
PDB entry 7gub coloured by chain, side view.
PDB entry 7gub coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mehlman T, Ginn HM, Keedy DA

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 1 Chain: A
Molecule details ›
Chain: A
Length: 321 amino acids
Theoretical weight: 37.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18031 (Residues: 1-321; Coverage: 74%)
Gene names: PTP1B, PTPN1
Sequence domains: Protein-tyrosine phosphatase

Ligands and Environments

1 bound ligand:
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P3121
Unit cell:
a: 91.037Å b: 91.037Å c: 106.951Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.271 0.27 0.304
Expression system: Escherichia coli

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