› 7hhm

X-ray diffraction
1.78Å resolution

PanDDA analysis group deposition -- Crystal structure of HRP-2 PWWP domain in complex with Z234898257

Released:
DOI: 10.2210/pdb7hhm/pdb
PDB entry 7hhm coloured by chain, front view.
PDB entry 7hhm coloured by chain, side view.
PDB entry 7hhm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Vantieghem T, Aslam NA, Osipov EM, Akele M, Van Belle S, Beelen S, Drexler M, Paulovcakova T, Lux V, Fearon D, Douangamath A, von Delft F, Christ F, Veverka V, Verwilst P, Van Aerschot A, Debyser Z, Strelkov SV
Eur J Med Chem 280 116960 (2024)
PMID: 39461037

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-566401 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatoma-derived growth factor-related protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 94 amino acids
Theoretical weight: 10.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z4V5 (Residues: 1-93; Coverage: 14%)
Gene names: HDGF2, HDGFL2, HDGFRP2, HRP2, UNQ785/PRO1604
Sequence domains: PWWP domain

Ligands and Environments

3 bound ligands:
Ligand SO4 6 x SO4
Ligand EDO 1 x EDO
Ligand UWD 2 x UWD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 41.387Å b: 42.061Å c: 158.488Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.252
Expression system: Escherichia coli

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