› 7jgz

X-ray diffraction
3.51Å resolution

Protocadherin gammaC4 EC1-4 crystal structure

Released:
DOI: 10.2210/pdb7jgz/pdb
PDB entry 7jgz coloured by chain, front view.
PDB entry 7jgz coloured by chain, side view.
PDB entry 7jgz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition.
Goodman KM, Katsamba PS, Rubinstein R, Ahlsén G, Bahna F, Mannepalli S, Dan H, Sampogna RV, Shapiro L, Honig B
OpenAccess logo Elife 11 (2022)
PMID: 35253643

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187594 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Cadherin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 429 amino acids
Theoretical weight: 47.01 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q91XX0 (Residues: 33-453; Coverage: 45%)
Gene name: Pcdhgc4
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
3 bound ligands:
Ligand MAN 2 x MAN
Ligand CA 9 x CA
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: I212121
Unit cell:
a: 75.22Å b: 115.68Å c: 194.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.223 0.271
Expression system: Homo sapiens

Quick links

Citations

1 review citation

The physiology of alternative splicing.
Marasco et al. (2023)
10 other articles

1 mention without citation

Astrocyte morphogenesis requires self-recognition.
Zipursky et al. (2024)