› 7jj8

X-ray diffraction
2.03Å resolution

Crystal structure of the Zn(II)-bound ZnuA-like domain of Streptococcus pneumoniae AdcA

Released:
DOI: 10.2210/pdb7jj8/pdb
PDB entry 7jj8 coloured by chain, front view.
PDB entry 7jj8 coloured by chain, side view.
PDB entry 7jj8 coloured by chain, top view.
Source organism: Streptococcus pneumoniae R6
Primary publication:
A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA.
Luo Z, Morey JR, Deplazes E, Motygullina A, Tan A, Ganio K, Neville SL, Eleftheriadis N, Isselstein M, Pederick VG, Paton JC, Cordes T, Harmer JR, Kobe B, McDevitt CA
OpenAccess logo mBio 12 (2021)
PMID: 33531394

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-568094 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc-binding lipoprotein AdcA Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 299 amino acids
Theoretical weight: 33.2 KDa
Source organism: Streptococcus pneumoniae R6
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8CWN2 (Residues: 27-325; Coverage: 62%)
Gene names: adcA, spr1975
Sequence domains: Zinc-uptake complex component A periplasmic

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P1
Unit cell:
a: 60.372Å b: 67.956Å c: 79.622Å
α: 92.275° β: 104.697° γ: 115.959°
R-values:
R R work R free
0.17 0.169 0.213
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Managing Manganese: The Role of Manganese Homeostasis in Streptococcal Pathogenesis.
Aggarwal et al. (2022)
4 other articles

2 mentions without citation

A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA.
Luo et al. (2021)
1 more