› 7jlo

Electron Microscopy
3.4Å resolution

Cryo-EM structure of human ATG9A in amphipols

Released:
DOI: 10.2210/pdb7jlo/pdb
PDB entry 7jlo coloured by chain, front view.
PDB entry 7jlo coloured by chain, side view.
PDB entry 7jlo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, Grishin NV, Forli S, Mizushima N, Otomo T
OpenAccess logo Nat Struct Mol Biol 27 1194-1201 (2020)
PMID: 33106659
Related structures: EMD-22375

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182248 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Autophagy-related protein 9A Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 578 amino acids
Theoretical weight: 66.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7Z3C6 (Residues: 1-578; Coverage: 69%)
Gene names: APG9L1, ATG9A
Sequence domains: Autophagy protein ATG9

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-22375
Expression system: Spodoptera frugiperda

Quick links

Citations

45 review citations

Autophagy in metabolic disease and ageing.
Kitada et al. (2021)
44 more

1 mention without citation

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Maeda et al. (2020)