› 7jlr

X-ray diffraction
2.2Å resolution

Crystal structure of Bacillus subtilis UppS in complex with JPD447

Released:
DOI: 10.2210/pdb7jlr/pdb
PDB entry 7jlr coloured by chain, front view.
PDB entry 7jlr coloured by chain, side view.
PDB entry 7jlr coloured by chain, top view.
Source organism: Bacillus subtilis
Primary publication:
Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria.
Workman SD, Day J, Farha MA, El Zahed SS, Bon C, Brown ED, Organ MG, Strynadka NCJ
J Med Chem 64 13540-13550 (2021)
PMID: 34473495

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isoprenyl transferase Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.81 KDa
Source organism: Bacillus subtilis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O31751 (Residues: 1-260; Coverage: 100%)
Gene names: BSU16530, uppS, yluA
Sequence domains: Putative undecaprenyl diphosphate synthase

Ligands and Environments

1 bound ligand:
Ligand V0D 1 x V0D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P43212
Unit cell:
a: 60.115Å b: 60.115Å c: 161.067Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.249
Expression system: Escherichia coli BL21(DE3)

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