› 7jlv

Electron Microscopy
3.8Å resolution

Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ

Released:
DOI: 10.2210/pdb7jlv/pdb
PDB entry 7jlv coloured by chain, front view.
PDB entry 7jlv coloured by chain, side view.
PDB entry 7jlv coloured by chain, top view.
Source organism: Nicotiana benthamiana
Primary publication:
Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.
Martin R, Qi T, Zhang H, Liu F, King M, Toth C, Nogales E, Staskawicz BJ
Science 370 (2020)
PMID: 33273074
Related structures: EMD-22381

Function and Biology Details

Reaction catalysed: 
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104118 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disease resistance protein Roq1 Chains: A, B, D, G
Molecule details ›
Chains: A, B, D, G
Length: 1306 amino acids
Theoretical weight: 150.65 KDa
Source organism: Nicotiana benthamiana
Expression system: Nicotiana benthamiana
UniProt:
  • Canonical: A0A290U7C4 (Residues: 1-1306; Coverage: 100%)
Gene name: ROQ1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ATP 4 x ATP
Ligand MG 4 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-22381
Expression system: Nicotiana benthamiana

Quick links

Citations

41 review citations

Thirty years of resistance: Zig-zag through the plant immune system.
Ngou et al. (2022)
40 more

2 mentions without citation

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.
Martin et al. (2020)
1 more