› 7jm9

Electron Microscopy
2.5Å resolution

Sheep Connexin-50 at 2.5 angstroms reoslution, Lipid Class 2

Released:
DOI: 10.2210/pdb7jm9/pdb
PDB entry 7jm9 coloured by chain, front view.
PDB entry 7jm9 coloured by chain, side view.
PDB entry 7jm9 coloured by chain, top view.
Source organism: Ovis aries
Primary publication:
Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å.
Flores JA, Haddad BG, Dolan KA, Myers JB, Yoshioka CC, Copperman J, Zuckerman DM, Reichow SL
OpenAccess logo Nat Commun 11 4331 (2020)
PMID: 32859914
Related structures: EMD-22390

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157358 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gap junction alpha-8 protein Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 440 amino acids
Theoretical weight: 49.22 KDa
Source organism: Ovis aries
UniProt:
  • Canonical: P55917 (Residues: 1-440; Coverage: 100%)
Gene name: GJA8
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand MC3 168 x MC3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-22390

Quick links

Citations

15 review citations

Peptidic Connexin43 Therapeutics in Cardiac Reparative Medicine.
Marsh et al. (2021)
14 more

3 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
2 more