7jmo

X-ray diffraction
2.36Å resolution

Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody COVA2-04

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-534800 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike protein S1 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 26.1 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
COVA2-04 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.14 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
COVA2-04 light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Mus musculus

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-1
Spacegroup: C2
Unit cell:
a: 197.246Å b: 84.678Å c: 57.301Å
α: 90° β: 99.58° γ: 90°
R-values:
R R work R free
0.197 0.195 0.238
Expression systems:
  • Trichoplusia ni
  • Mus musculus