› 7jpd

X-ray diffraction
2.95Å resolution

Crystal structure of the trimeric full length mature hemagglutinin from influenza A virus A/Fort Monmouth/1/1947

Released:
DOI: 10.2210/pdb7jpd/pdb
PDB entry 7jpd coloured by chain, front view.
PDB entry 7jpd coloured by chain, side view.
PDB entry 7jpd coloured by chain, top view.
Source organism: Influenza A virus (A/Fort Monmouth/1/1947(H1N1))
Primary publication:
Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site.
Ghafoori SM, Petersen GF, Conrady DG, Calhoun BM, Stigliano MZZ, Baydo RO, Grice R, Abendroth J, Lorimer DD, Edwards TE, Forwood JK
OpenAccess logo Sci Rep 13 6940 (2023)
PMID: 37117205

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-216405 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 329 amino acids
Theoretical weight: 36.86 KDa
Source organism: Influenza A virus (A/Fort Monmouth/1/1947(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q20MG8 (Residues: 18-344; Coverage: 58%)
Gene name: HA
Sequence domains: Haemagglutinin
Hemagglutinin HA2 chain Chains: a, b, c, d, e, f
Molecule details ›
Chains: a, b, c, d, e, f
Length: 170 amino acids
Theoretical weight: 19.52 KDa
Source organism: Influenza A virus (A/Fort Monmouth/1/1947(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q20MG8 (Residues: 345-509; Coverage: 29%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
3 bound ligands:
Ligand NAG 11 x NAG
Ligand EDO 1 x EDO
Ligand IOD 76 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 131.79Å b: 142.36Å c: 234.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.255 0.254 0.286
Expression system: Trichoplusia ni

Quick links

Citations

1 mention without citation

Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site.
Ghafoori et al. (2023)