› 7jpt

Electron Microscopy
3.2Å resolution

Structure of an endocytic receptor

Released:
DOI: 10.2210/pdb7jpt/pdb
PDB entry 7jpt coloured by chain, front view.
PDB entry 7jpt coloured by chain, side view.
PDB entry 7jpt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The cryo-EM structure of the endocytic receptor DEC-205.
Gully BS, Venugopal H, Fulcher AJ, Fu Z, Li J, Deuss FA, Llerena C, Heath WR, Lahoud MH, Caminschi I, Rossjohn J, Berry R
OpenAccess logo J Biol Chem 296 100127
PMID: 33257321
Related structures: EMD-22422

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129974 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Lymphocyte antigen 75 Chain: A
Molecule details ›
Chain: A
Length: 1693 amino acids
Theoretical weight: 195.23 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O60449 (Residues: 30-1722; Coverage: 100%)
Gene names: CD205, CLEC13B, LY75
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-22422
Expression system: Homo sapiens

Quick links

Citations

4 review citations

The mannose receptor ligands and the macrophage glycome.
Cummings RD. (2022)
3 more

2 mentions without citation

The cryo-EM structure of the endocytic receptor DEC-205.
Gully et al. (2021)
1 more