› 7jsk

Electron Microscopy
3.04Å resolution

Structure of the NaCT-Citrate complex

Released:
DOI: 10.2210/pdb7jsk/pdb
PDB entry 7jsk coloured by chain, front view.
PDB entry 7jsk coloured by chain, side view.
PDB entry 7jsk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and inhibition mechanism of the human citrate transporter NaCT.
Sauer DB, Song J, Wang B, Hilton JK, Karpowich NK, Mindell JA, Rice WJ, Wang DN
OpenAccess logo Nature 591 157-161 (2021)
PMID: 33597751
Related structures: EMD-22457

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183276 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/citrate cotransporter Chains: A, B
Molecule details ›
Chains: A, B
Length: 568 amino acids
Theoretical weight: 63.11 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q86YT5 (Residues: 1-568; Coverage: 100%)
Gene names: NACT, SLC13A5
Sequence domains: Sodium:sulfate symporter transmembrane region

Ligands and Environments

3 bound ligands:
Ligand NAG 2 x NAG
Ligand CIT 2 x CIT
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.04Å
Relevant EMDB volumes: EMD-22457
Expression system: Trichoplusia ni

Quick links

Citations

9 review citations

Molecular Mechanisms of the SLC13A5 Gene Transcription.
Li et al. (2021)
8 more

9 mentions without citation

New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium.
Giacomini et al. (2022)
8 more