› 7jx7

X-ray diffraction
1.75Å resolution

BRD2-BD2 in complex with a diacetylated-H2A.Z peptide

Released:
DOI: 10.2210/pdb7jx7/pdb
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PDB entry 7jx7 coloured by chain, top view.
Source organisms:
Primary publication:
The bromodomains of BET family proteins can recognize diacetylated histone H2A.Z.
Patel K, Solomon PD, Walshe JL, Low JKK, Mackay JP
Protein Sci 30 464-476 (2021)
PMID: 33247496

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150467 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 13.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 347-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain
Diacetylated-H2A.Z peptide Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 601 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ALY 2 x ALY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Unit cell:
a: 32.19Å b: 52.457Å c: 71.759Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.21
Expression systems:
  • Escherichia coli
  • Not provided

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Citations

2 review citations

The Functions of BET Proteins in Gene Transcription of Biology and Diseases.
Cheung et al. (2021)
1 more

1 mention without citation

The bromodomains of BET family proteins can recognize diacetylated histone H2A.Z.
Patel et al. (2021)

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